Abstract Background Multiple myeloma (MM) remains an incurable malignancy, despite the advent of therapies such as proteosome inhibitors (PIs) that disrupt protein homeostasis and induce ER stress.We have pursued inhibition of geranylgeranyl diphosphate synthase (GGDPS) as a novel mechanism by which to target protein homeostasis in MM cells.GGDPS i

Gray-bellied Hawk (Accipiter poliogaster) is a diurnal raptor with a distribution range and movements poorly known.A juvenile was recorded in Costa Rica in 2008 and 2009 for in mel axolotl the Caribbean lowlands.In this note we reported the first adult observation for Costa Rica and a new locality.Even though is uncertain how this species g35 coupe

Collectin liver 1 (CL-L1, alias collectin 10) and collectin kidney 1 (CL-K1, alias collectin 11) are oligomeric pattern recognition molecules associated with the complement system, and mutations in either of their genes may lead to deficiency and developmental defects.The two collectins are reportedly localized and synthesized in the liver, kidneys

Abstract Background Proton beam therapy is promising for the treatment of head and neck cancer (HNC), but it is sensitive to uncertainties in patient positioning and particle range.Studies have shown that the planning target volume (PTV) concept may not be sufficient to ensure robustness of the target coverage.A few planning studies have considered

The ductus venosus is a fetal vessel that functions importantly in the transfer of oxygen-and nutrient-rich blood from the underwater treasures sunken medallion umbilical vein to vital organs.Its control under active regulation and its anatomy result in a flow-velocity profile that is typically forward throughout the cardiac cycle.This forward card